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Does This Patient Have an Underactive Thyroid?

From age, sex, medication history and thyroid test results, does this patient have hypothyroidism? Most tests come back normal, so a score that flags the likely cases saves clinicians time.

Use caseHealthcarePredictionModel evaluation

The table

Patient records with medication and treatment history and thyroid hormone tests, labelled hypothyroid or not. It's in Welt's research catalogue as Hypothyroid, 3,163 rows by 26 columns, licensed CC BY 4.0. The catalogue measures its signal at 0.70. At 3,163 rows and 25 features, TabICLv2 and Kumo Tabular Medium take the table as it is. The others can't take a table this size, so the walkthrough leaves them out.

Walkthrough

  1. Load it from the catalogue

    Find the table, read its recorded target and print the column names.

    import pandas as pd
    from welt import Client
    
    with Client() as client:
        item = client.research_datasets(q="hypothyroid", limit=1)["items"][0]
        info = client.research_dataset(item["id"])
        data = client.load_research_dataset(item["id"])
    
    target = info["targets"][0]
    target = target["name"] if isinstance(target, dict) else target
    print([column["name"] for column in info["schema"]], target)
  2. Pick the rows

    Set aside 20 rows to predict at the end, and keep the rest for the models to learn from.

    known = data.dropna(subset=[target])
    new_rows = known.sample(20, random_state=1)
    table = known.drop(new_rows.index)
  3. Compare the models and predict

    The models compete on the same folds against a simple guess, then the top-ranked one is fitted on the whole table. ROC AUC runs from 0.5, a coin toss, to 1, a perfect ranking, and a lower Brier score means the probabilities can be trusted more. The last table puts each prediction next to the real answer.

    with Client() as client:
        evaluation = client.evaluate(table, target, task="classification", seed=7,
                                     models=["tabicl-v2", "kumo-medium"])
        model = evaluation.fit()
    
    print(evaluation.summary()[["name", "rank", "roc_auc_mean", "brier_mean"]])
    features = new_rows.drop(columns=target)
    print(pd.DataFrame({"actual": new_rows[target].values, "predicted": model.predict(features),
                        "probability": model.predict_proba(features).max(axis=1)}))

What you get

A probability per patientFlag the cases most likely to need treatment.
Rare cases checkedThe leaderboard shows how the models handle the smaller class.
Missing tests handledRecords with gaps go in as they are.

Try it

Use Open with to run the research datasets notebook in Colab, Kaggle or Jupyter and search for "hypothyroid", or run the code above after pip install "welt-client[parquet]".